Article
Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies.
Human molecular genetics - 15 Sept 2006
Dempfle Astrid, Wudy Stefan A, Saar Kathrin, Hagemann Sandra, Friedel Susann, Scherag André, Berthold Lars D, Alzen Gerhard, Gortner Ludwig, Blum Werner F, Hinney Anke, Nürnberg Peter, Schäfer Helmut, Hebebrand Johannes
Abstract excerpt
Stature is a highly heritable trait under both polygenic and major gene control. We aimed to identify genetic regions linked to idiopathic short stature (ISS) in childhood, through a whole genome scan in 92 families each with two affected children with ISS, including constitutional delay of growth and puberty and familial short stature. Linkage analysis was performed for ISS, height and bone age retardation....
Topics
- Adolescent
- Adult
- Age Determination by Skeleton
- Body Height
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 15