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Article

Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning.

Journal of biomedical science - 7 Nov 2019

Wong Henry Sung-Ching, Lin Ying-Ju, Lu Hsing-Fang, Liao Wen-Ling, Chen Chien-Hsiun, Wu Jer-Yuarn, Chang Wei-Chiao, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available. METHODS: Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery...

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Identifiers

PMID: 31699087
DOI: 10.1186/s12929-019-0581-2
PMCID: PMC6836357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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