Article
MSB: a mean-shift-based approach for the analysis of structural variation in the genome.
Genome research - 1 Jan 2009
Wang Lu-Yong, Abyzov Alexej, Korbel Jan O, Snyder Michael, Gerstein Mark
Abstract excerpt
Genome structural variation includes segmental duplications, deletions, and other rearrangements, and array-based comparative genomic hybridization (array-CGH) is a popular technology for determining this. Drawing relevant conclusions from array-CGH requires computational methods for partitioning the chromosome into segments of elevated, reduced, or unchanged copy number. Several approaches have been described,...
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