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Article

Sonic hedgehog is essential for first pharyngeal arch development.

Pediatric research - 1 Mar 2006

Yamagishi Chihiro, Yamagishi Hiroyuki, Maeda Jun, Tsuchihashi Takatoshi, Ivey Kathryn, Hu Tonghuan, Srivastava Deepak

Abstract excerpt

The secreted protein sonic hedgehog (Shh) is essential for normal development of many organs. Targeted disruption of Shh in mouse leads to near complete absence of craniofacial skeletal elements at birth, and mutation of SHH in human causes holoprosencephaly (HPE), frequently associated with defects of derivatives of pharyngeal arches. To investigate the role of Shh signaling in early pharyngeal arch development,...

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Source

Identifiers

PMID: 16492970
DOI: 10.1203/01.pdr.0000199911.17287.3e

Genes

SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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