Article
Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study).
Osteoarthritis and cartilage - 1 Jun 2009
Limer K L, Tosh K, Bujac S R, McConnell R, Doherty S, Nyberg F, Zhang W, Doherty M, Muir K R, Maciewicz R A
Abstract excerpt
OBJECTIVE: Published studies have tested over 90 genes for association with osteoarthritis (OA), but few positives reported have been independently replicated. Using a new case-control study, our aim was to attempt the replication of findings from 12 genes reported to have significant genetic ass...
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