Article
Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study).
Osteoarthritis and cartilage - 1 Jun 2009
Limer K L, Tosh K, Bujac S R, McConnell R, Doherty S, Nyberg F, Zhang W, Doherty M, Muir K R, Maciewicz R A
Abstract excerpt
OBJECTIVE: Published studies have tested over 90 genes for association with osteoarthritis (OA), but few positives reported have been independently replicated. Using a new case-control study, our aim was to attempt the replication of findings from 12 genes reported to have significant genetic association with OA and to further examine the role of genetic variation in six of these genes. METHODS: A case-control...
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