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Article

Involvement of the TPR2 subdomain movement in the activities of phi29 DNA polymerase.

Nucleic acids research - 1 Jan 2009

Rodríguez Irene, Lázaro José María, Salas Margarita, de Vega Miguel

Abstract excerpt

The polymerization domain of phi29 DNA polymerase acquires a toroidal shape by means of an arch-like structure formed by the specific insertion TPR2 (Terminal Protein Region 2) and the thumb subdomain. TPR2 is connected to the fingers and palm subdomains through flexible regions, suggesting that it can undergo conformational changes. To examine whether such changes take place, we have constructed a phi29 DNA...

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Identifiers

PMID: 19033368
DOI: 10.1093/nar/gkn928
PMCID: PMC2615600

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Involvement of the TPR2 subdomain movement in the activities of phi29 DNA polymerase.PMID 19033368Read ↗

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