Article
Involvement of residues of the 29 terminal protein intermediate and priming domains in the formation of a stable and functional heterodimer with the replicative DNA polymerase.
Nucleic acids research - 1 May 2012
del Prado Alicia, Villar Laurentino, de Vega Miguel, Salas Margarita
Abstract excerpt
Bacteriophage Φ29 genome consists of a linear double-stranded DNA with a terminal protein (TP) covalently linked to each 5' end (TP-DNA) that together with a specific sequence constitutes the replication origins. To initiate replication, the DNA polymerase forms a heterodimer with a free TP that recognizes the origins and initiates replication using as primer the hydroxyl group of TP residue Ser232. The 3D...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.