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Article

The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition.

The EMBO journal - 22 Mar 2006

Kamtekar Satwik, Berman Andrea J, Wang Jimin, Lázaro José M, de Vega Miguel, Blanco Luis, Salas Margarita, Steitz Thomas A

Abstract excerpt

The absolute requirement for primers in the initiation of DNA synthesis poses a problem for replicating the ends of linear chromosomes. The DNA polymerase of bacteriophage phi29 solves this problem by using a serine hydroxyl of terminal protein to prime replication. The 3.0 A resolution structure shows one domain of terminal protein making no interactions, a second binding the polymerase and a third domain...

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Identifiers

PMID: 16511564
DOI: 10.1038/sj.emboj.7601027
PMCID: PMC1422159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition.PMID 16511564Read ↗

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