Article
Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2017
Muranen Taru A, Greco Dario, Blomqvist Carl, Aittomäki Kristiina, Khan Sofia, Hogervorst Frans, Verhoef Senno, Pharoah Paul D P, Dunning Alison M, Shah Mitul, Luben Robert, Bojesen Stig E, Nordestgaard Børge G, Schoemaker Minouk, Swerdlow Anthony, García-Closas Montserrat, Figueroa Jonine, Dörk Thilo, Bogdanova Natalia V, Hall Per, Li Jingmei, Khusnutdinova Elza, Bermisheva Marina, Kristensen Vessela, Borresen-Dale Anne-Lise, Peto Julian, Dos Santos Silva Isabel, Couch Fergus J, Olson Janet E, Hillemans Peter, Park-Simon Tjoung-Won, Brauch Hiltrud, Hamann Ute, Burwinkel Barbara, Marme Frederik, Meindl Alfons, Schmutzler Rita K, Cox Angela, Cross Simon S, Sawyer Elinor J, Tomlinson Ian, Lambrechts Diether, Moisse Matthieu, Lindblom Annika, Margolin Sara, Hollestelle Antoinette, Martens John W M, Fasching Peter A, Beckmann Matthias W, Andrulis Irene L, Knight Julia A, Anton-Culver Hoda, Ziogas Argyrios, Giles Graham G, Milne Roger L, Brenner Hermann, Arndt Volker, Mannermaa Arto, Kosma Veli-Matti, Chang-Claude Jenny, Rudolph Anja, Devilee Peter, Seynaeve Caroline, Hopper John L, Southey Melissa C, John Esther M, Whittemore Alice S, Bolla Manjeet K, Wang Qin, Michailidou Kyriaki, Dennis Joe, Easton Douglas F, Schmidt Marjanka K, Nevanlinna Heli
Abstract excerpt
PURPOSE: CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have investigated this empirically using data from the Breast Cancer Association Consortium (BCAC). METHODS: Using...
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