Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.

doi:10.1007/978-1-0716-0640-7_30

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Article

Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Marchi Saverio, Retta Saverio Francesco, Pinton Paolo

Abstract excerpt

Cerebral cavernous malformations (CCM) is a familial or sporadic rare disorder that is characterized by capillary vascular lesions with a mulberry-like appearance on MRI scans. Three distinct genes have been associated to CCM disease, known as CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10. Loss-of-fu...

Topics

Autophagy
Biomarkers
Cells, Cultured
Disease Susceptibility
Endothelial Cells
Fluorescent Antibody Technique
Hemangioma, Cavernous, Central Nervous System
Humans
Microtubule-Associated Proteins
Mutation
Protein Aggregates
Protein Aggregation, Pathological
Sequestosome-1 Protein

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Identifiers

PMID: 32524569
DOI: 10.1007/978-1-0716-0640-7_30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-32524569-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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