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Article

Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome.

Investigative ophthalmology & visual science - 1 Mar 2009

Trantow Colleen M, Mao Mao, Petersen Greg E, Alward Erin M, Alward Wallace L M, Fingert John H, Anderson Michael G

Abstract excerpt

PURPOSE: Human eyes with exfoliation syndrome (XFS) exhibit a distinctive pattern of iris transillumination defects that are recapitulated in Lyst mutant mice carrying the beige allele. The purpose of this study was to determine the anatomic basis for Lyst-mediated transillumination defects, test...

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Source

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Identifiers

PMID: 19029039
DOI: 10.1167/iovs.08-2791
PMCID: PMC2693230

Genes

LYST
LOXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19029039-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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