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Article

Mechanisms of RND multidrug efflux pumps.

Biochimica et biophysica acta - 1 May 2009

Nikaido Hiroshi, Takatsuka Yumiko

Abstract excerpt

RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins. AcrAB-TolC complex of Escherichia coli, which pumps out a very wide range of drugs, has...

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Identifiers

PMID: 19026770
DOI: 10.1016/j.bbapap.2008.10.004
PMCID: PMC2696896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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