Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

Abstract excerpt

Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we have re-evaluated the likelihood that the different PARK loci (defined using clinical criteria for disease) may be misleading attempts to find common pathways to pathogenesis. Rather, we suggest, grouping the different loci which lead to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Lysosomal Storage Disorders Research
• Share to Neurological diseases and metabolism
• Share to Parkinson's Disease Mechanisms and Treatments