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Article

Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers.

Oncogene - 3 Nov 2005

Lièvre Astrid, Landi Bruno, Côté Jean-François, Veyrie Nicolas, Zucman-Rossi Jessica, Berger Anne, Laurent-Puig Pierre

Abstract excerpt

The KLF6 gene encodes the Krüppel-like factor 6, a transcription factor that has been individualized as a tumor-suppressor gene involved in the regulation of cell proliferation and differentiation. Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, astrocytic gliomas and hepatocellular carcinomas. The aims of the study was to confirm the...

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Share to Chromosomes, Human, Pair 10
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Kruppel-Like Transcription Factors

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 16044160
DOI: 10.1038/sj.onc.1208867

Genes

KLF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers.PMID 16044160Read ↗

Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer☆Semantic proximity Read ↗

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KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.Semantic proximity Read ↗

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