Article
Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers.
The Journal of rheumatology - 1 Dec 2016
Jung Seung-Hyun, Cho Sung-Min, Yim Seon-Hee, Kim So-Hee, Park Hyeon-Chun, Cho Mi-La, Shim Seung-Cheol, Kim Tae-Hwan, Park Sung-Hwan, Chung Yeun-Jun
Abstract excerpt
OBJECTIVE: To develop a genotype-based ankylosing spondylitis (AS) risk prediction model that is more sensitive and specific than HLA-B27 typing. METHODS: To develop the AS genetic risk scoring (AS-GRS) model, 648 individuals (285 cases and 363 controls) were examined for 5 copy number variants (CNV), 7 single-nucleotide polymorphisms (SNP), and an HLA-B27 marker by TaqMan assays. The AS-GRS model was developed...
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