Article
The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae.
Molecular microbiology - 1 Jun 2001
Wysocki R, Chéry C C, Wawrzycka D, Van Hulle M, Cornelis R, Thevelein J M, Tamás M J
Abstract excerpt
The Saccharomyces cerevisiae FPS1 gene encodes a glycerol channel protein involved in osmoregulation. We present evidence that Fps1p mediates influx of the trivalent metalloids arsenite and antimonite in yeast. Deletion of FPS1 improves tolerance to arsenite and potassium antimonyl tartrate. Under high osmolarity conditions, when the Fps1p channel is closed, wild-type cells show the same degree of As(III) and...
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