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Article

Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2008

Chiang Huei-Hsin, Rosvall Lina, Brohede Jesper, Axelman Karin, Björk Behnosh F, Nennesmo Inger, Robins Tiina, Graff Caroline

Abstract excerpt

BACKGROUND: Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by cognitive impairment, language dysfunction, and/or changes in personality. Recently it has been shown that progranulin (GRN) mutations can cause FTD as well as other neurodegenerative phenotypes. METHODS: DNA from 30 family members, of whom seven were diagnosed with FTD, in the Karolinska family was available for GRN...

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Identifiers

PMID: 19012866
DOI: 10.1016/j.jalz.2008.09.001

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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