Article
Analysis of the stathmin rs182455 single nucleotide promoter polymorphism in patients with multiple sclerosis.
Journal of neurogenetics - 1 Jan 2008
Buttmann Mathias, Nowak Eva, Kroner Antje, Hemmer Bernhard, Lesch Klaus-Peter, Rieckmann Peter
Abstract excerpt
Stathmin, a steroid-responsive regulatory protein of oligodendrocyte migration and survival, is highly expressed in active brain lesions of patients with multiple sclerosis (MS) and probably involved in myelin degeneration and repair. Here, we analyzed a single nucleotide polymorphism (rs182455) within the stathmin promoter that is close to a putative steroid-responsive element and has a high minor allelic...
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