Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy

5 Jan 2006

Abstract excerpt

Motor neuron degeneration is the predominant pathological feature of spinal muscular atrophy (SMA). In patients with severe forms of the disease, additional sensory abnormalities have been reported. However, it is not clear whether the loss of sensory neurons is a common feature in severe forms of the disease, how many neurons are lost and how loss of sensory neurons compares with motor neuron degeneration. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Anomalies and Fetal Surgery
Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16396995
DOI: 10.1093/hmg/ddi467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophyPMID 16396995Read ↗

Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron DysfunctionSemantic proximity Read ↗

Smn deficiency causes neuritogenesis and neurogenesis defects in the retinal neurons of a mouse model of spinal muscular atrophySemantic proximity Read ↗

Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.Semantic proximity Read ↗

Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophySemantic proximity Read ↗

Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy.Semantic proximity Read ↗

SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMASemantic proximity Read ↗

Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophySemantic proximity Read ↗

SMN is required for sensory-motor circuit function in Drosophila.Semantic proximity Read ↗

Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophySemantic proximity Read ↗

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophySemantic proximity Read ↗

Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse modelSemantic proximity Read ↗

Limited phenotypic effects of selectively augmenting the SMN protein in the neurons of a mouse model of severe spinal muscular atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.