Article
Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein.
Human gene therapy - 1 Mar 2001
Lin A H, Kasahara N, Wu W, Stripecke R, Empig C L, Anderson W F, Cannon P M
Abstract excerpt
The entry of retroviral vectors into cells requires two events: binding to a cell surface receptor and the subsequent fusion of viral and cellular membranes. The host range of a vector is therefore determined largely by the receptor specificity of the fusion protein contained in the outer viral envelope. Previous attempts to generate targeted retroviral vectors have included the addition of targeting ligands to...
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