Article
Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein.
Human gene therapy - 1 Mar 2001
Lin A H, Kasahara N, Wu W, Stripecke R, Empig C L, Anderson W F, Cannon P M
Abstract excerpt
The entry of retroviral vectors into cells requires two events: binding to a cell surface receptor and the subsequent fusion of viral and cellular membranes. The host range of a vector is therefore determined largely by the receptor specificity of the fusion protein contained in the outer viral e...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.