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Article

Tissue-Specific Targeting of Retroviral Vectors Through Ligand-Receptor Interactions

25 Nov 1994

Abstract excerpt

The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin...

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PMID: 7973726
DOI: 10.1126/science.7973726

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