Article
Low penetrance breast cancer predisposition SNPs are site specific.
Breast cancer research and treatment - 1 Sept 2009
Mcinerney Niall, Colleran Gabrielle, Rowan Andrew, Walther Axel, Barclay Ella, Spain Sarah, Jones Angela M, Tuohy Stephen, Curran Catherine, Miller Nicola, Kerin Michael, Tomlinson Ian, Sawyer Elinor
Abstract excerpt
Large scale association studies have identified low penetrance susceptibility alleles that predispose to breast cancer. A locus on chromosome 8q24.21 has been shown to harbour variants that predispose to breast, ovarian, colorectal and prostate cancer. The finding of risk variants clustering at 8...
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