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Article

DKK1 inhibits canonical Wnt signaling in human papillomavirus-positive penile cancer cells

9 Nov 2021

Abstract excerpt

Penile squamous cell cancer (PSCC) is the most frequent penile malignant disease. Infections with human papillomaviruses (HPV) are a major etiologic driver of PSCC. However, the molecular details of the underlying carcinogenesis are understudied because of rare clinical specimens and missing cell lines. Here, we investigated if the expression of high-risk HPV16 oncogenes causes an augmentation of the Wnt pathway...

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PMID: 34773828
DOI: 10.1016/j.tranon.2021.101267

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