Article
Haematopoietic repopulating activity in human cord blood CD133+ quiescent cells.
Bone marrow transplantation - 1 Apr 2009
Boxall S A, Cook G P, Pearce D, Bonnet D, El-Sherbiny Y M, Blundell M P, Howe S J, Leek J P, Markham A F, de Wynter E A
Abstract excerpt
We have demonstrated previously that cord blood CD133(+) cells isolated in the G(0) phase of the cell cycle are highly enriched for haematopoietic stem cell (HSC) activity, in contrast to CD133(+)G(1) cells. Here, we have analysed the phenotype and functional properties of this population in more detail. Our data demonstrate that a large proportion of the CD133(+)G(0) cells are CD38 negative (60.4%) and have high...
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