CD133 (Prominin) Negative Human Neural Stem Cells Are Clonogenic and Tripotent

Abstract excerpt

BACKGROUND: CD133 (Prominin) is widely used as a marker for the identification and isolation of neural precursor cells from normal brain or tumor tissue. However, the assumption that CD133 is expressed constitutively in neural precursor cells has not been examined. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we demonstrate that CD133 and a second marker CD15 are expressed heterogeneously in uniformly...

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