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Article

Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.

Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2009

Ruaño Gualberto, Bernene James, Windemuth Andreas, Bower Bruce, Wencker Detlef, Seip Richard L, Kocherla Mohan, Holford Theodore R, Petit William A, Hanks Steven

Abstract excerpt

BACKGROUND: The thiazolidinediones (TZDs) improve tissue sensitivity to insulin in patients with type II diabetes, resulting in reduced levels of fasting blood glucose and glycated hemoglobin. However, TZDs unpredictably demonstrate adverse effects of increased body weight, fluid retention, and edema. The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18996102
DOI: 10.1016/j.cca.2008.10.009

Genes

ADORA1
ADIPOR2
APOH
CCL2
GHRH
GYS1
NPY
OLR1
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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