Article
Pharmacogenetic relevance of the CYP2C9*3 allele in a tenoxicam bioequivalence study performed on Spaniards.
Pharmacological research - 1 Jan 2009
Peiró A M, Novalbos J, Zapater P, Moreu R, López-Rodríguez R, Rodríguez V, Abad-Santos F, Horga J F
Abstract excerpt
We performed a study to quantify CYP2C9 and CYP2C8 alleles influence on the variability observed in tenoxicam pharmacokinetic (PK) and implication in a bioequivalence study design performed on Spaniards. Eighteen healthy volunteers were included in an open, randomized, crossover, phase I bioequivalence study. Significant increases were found in CYP2C9*3 alleles vs. *1 and *2 in AUC(0-infinity) (median (min-max)):...
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