Article
Influence of CYP2C9 genotypes on the pharmacokinetics and pharmacodynamics of piroxicam.
Clinical pharmacology and therapeutics - 1 Oct 2005
Perini Jamila A, Vianna-Jorge Rosane, Brogliato Ariane R, Suarez-Kurtz Guilherme
Abstract excerpt
OBJECTIVE: Our objective was to evaluate the influence of cytochrome P450 (CYP) 2C9 polymorphisms on the pharmacokinetics and pharmacodynamics of the nonsteroidal anti-inflammatory drug piroxicam. METHODS: Thirty-five healthy subjects with CYP2C9 genotypes *1/*1 (n=17), *1/*2 (n=9), and *1/*3 (n=...
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