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Article

The role of active site glutamate residues in catalysis of Rhodobacter capsulatus xanthine dehydrogenase.

The Journal of biological chemistry - 24 Sept 2004

Leimkühler Silke, Stockert Amy L, Igarashi Kiyohiko, Nishino Takeshi, Hille Russ

Abstract excerpt

Xanthine dehydrogenase (XDH) from the bacterium Rhodobacter capsulatus catalyzes the hydroxylation of xanthine to uric acid with NAD+ as the electron acceptor. R. capsulatus XDH forms an (alphabeta)2 heterotetramer and is highly homologous to homodimeric eukaryotic xanthine oxidoreductases. Here we first describe reductive titration and steady state kinetics on recombinant wild-type R. capsulatus XDH purified...

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Identifiers

PMID: 15265866
DOI: 10.1074/jbc.M405778200

Genes

XDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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