Article

A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level

2020-10-23

Abstract excerpt

The majority of seizures recorded in humans and experimental animal models can be described by a generic phenomenological mathematical model, The Epileptor. In this model, seizure-like events (SLEs) are driven by a slow variable and occur via saddle node (SN) and homoclinic bifurcations at seizure onset and offset, respectively. Here we investigated SLEs at the single cell level using a biophysically relevant neur...

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Literature Corpus work: fc986488-fcfd-5b31-acf6-1a70d7d69f59
DOI: 10.1101/2020.10.23.352021

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