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Article

Role of CCL3L1-CCR5 genotypes in the epidemic spread of HIV-1 and evaluation of vaccine efficacy.

PloS one - 1 Jan 2008

Kulkarni Hemant, Marconi Vincent C, Agan Brian K, McArthur Carole, Crawford George, Clark Robert A, Dolan Matthew J, Ahuja Sunil K

Abstract excerpt

BACKGROUND: Polymorphisms in CCR5, the major coreceptor for HIV, and CCL3L1, a potent CCR5 ligand and HIV-suppressive chemokine, are determinants of HIV-AIDS susceptibility. Here, we mathematically modeled the potential impact of these genetic factors on the epidemic spread of HIV, as well as on its prevention. METHODS AND RESULTS: Ro, the basic reproductive number, is a fundamental concept in explaining the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18989363
DOI: 10.1371/journal.pone.0003671
PMCID: PMC2576446

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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