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Article

Are Clade Specific HIV Vaccines a Necessity? An Analysis Based on Mathematical Models.

EBioMedicine - 1 Dec 2015

Dimitrov Dobromir, Kublin James G, Ramsey Scott, Corey Lawrence

Abstract excerpt

As HIV-1 envelope immune responses are critical to vaccine related protection, most candidate HIV vaccines entering efficacy trials are based upon a clade specific design. This need for clade specific vaccine prototypes markedly reduces the implementation of potentially effective HIV vaccines. We utilized a mathematical model to determine the effectiveness of immediate roll-out of a non-clade matched vaccine with...

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Identifiers

PMID: 26844286
DOI: 10.1016/j.ebiom.2015.11.009
PMCID: PMC4703729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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