Article
Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children.
AIDS (London, England) - 27 Mar 2009
Shostakovich-Koretskaya Ludmila, Catano Gabriel, Chykarenko Zoya A, He Weijing, Gornalusse German, Mummidi Srinivas, Sanchez Racquel, Dolan Matthew J, Ahuja Seema S, Clark Robert A, Kulkarni Hemant, Ahuja Sunil K
Abstract excerpt
OBJECTIVE: CCL3L and CCL4L genes encode HIV-suppressive chemokines, colocalize on chromosome 17q12 and have copy number variation. Copy number variation of CCL3L associates with HIV-AIDS susceptibility. Here, we determined the influence of the combinatorial content of distinct CCL3L and CCL4L genes on HIV-AIDS susceptibility. METHODS: By designing gene-specific assays, the association between doses of all CCL3L...
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