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Article

Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis.

Virology - 5 Jan 2009

Zehbe Ingeborg, Richard Christina, DeCarlo Correne A, Shai Anny, Lambert Paul F, Lichtig Hava, Tommasino Massimo, Sherman Levana

Abstract excerpt

L83V-related variants of human papillomavirus (HPV) 16 E6, exemplified by the Asian-American variant Q14H/H78Y/L83V, were shown to be more prevalent than E6 prototype in progressing lesions and cervical cancer. We evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as well as the prototype in a model of human normal immortalized keratinocytes (NIKS). All E6...

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Identifiers

PMID: 18986660
DOI: 10.1016/j.virol.2008.09.036
PMCID: PMC2945146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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