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Article

E6/E7 Functional Differences among Two Natural Human Papillomavirus 18 Variants in Human Keratinocytes.

Viruses - 10 Jun 2021

Nunes Emily Montosa, Talpe-Nunes Valéria, Sobrinho João Simão, Ferreira Silvaneide, Lino Vanesca de Souza, Termini Lara, Silva Gabriela Ávila Fernandes, Boccardo Enrique, Villa Luisa Lina, Sichero Laura

Abstract excerpt

It is suggested that HPV-18 variants from the A lineage have higher oncogenic potential compared to B variants. Some studies show uneven distribution of HPV-18 variants in cervical adenocarcinomas and squamous cell carcinomas. Regarding HPV-18 variants' functions, the few studies reported focus on E6, and none were performed using natural host cells. Here, we immortalized primary human keratinocytes (PHKs) with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34200583
DOI: 10.3390/v13061114
PMCID: PMC8228617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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