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Article

Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential.

Molecular cancer - 24 Jun 2011

Zehbe Ingeborg, Lichtig Hava, Westerback Ashley, Lambert Paul F, Tommasino Massimo, Sherman Levana

Abstract excerpt

The aim of this study was to determine whether low prevalence human papillomavirus (HPV) 16 E6 variants differ from high prevalence types in their functional abilities. We evaluated functions relevant to carcinogenesis for the rarely-detected European variants R8Q, R10G and R48W as compared to the commonly detected L83V. Human immortalized keratinocytes (NIKS) stably transduced with the E6 variants were used in...

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Identifiers

PMID: 21702904
DOI: 10.1186/1476-4598-10-77
PMCID: PMC3144020

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