Cohort of Iranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects.

doi:10.1586/1744666X.2016.1139451

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Cohort of Iranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects.

Expert review of clinical immunology - 1 Jan 2016

Abolhassani Hassan, Vitali Massimiliano, Lougaris Vassilios, Giliani Silvia, Parvaneh Nima, Parvaneh Leila, Mirminachi Babak, Cheraghi Taher, Khazaei Hosseinali, Mahdaviani Seyed Alireza, Kiaei Fatemeh, Tavakolinia Naiimeh, Mohammadi Javad, Negahdari Babak, Rezaei Nima, Hammarstrom Lennart, Plebani Alessandro, Aghamohammadi Asghar

Abstract excerpt

OBJECTIVES: Impairment in early B-cell development can cause a predominantly antibody deficiency with severe depletion of peripheral B-cells. Mutations in the gene encoding for Bruton's-tyrosine-kinase (BTK) and the components of the pre-B-cell receptor complex or downstream signaling molecules have been related to this defect in patients with agammaglobulinemia. METHODS: Iranian patients with congenital...

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PMID: 26910880
DOI: 10.1586/1744666X.2016.1139451

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