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Article

Genome 3′-end repair in dengue virus type 2

30 Oct 2008

Abstract excerpt

Genomes of RNA viruses encounter a continual threat from host cellular ribonucleases. Therefore, viruses have evolved mechanisms to protect the integrity of their genomes. To study the mechanism of 3'-end repair in dengue virus-2 in mammalian cells, a series of 3'-end deletions in the genome were evaluated for virus replication by detection of viral antigen NS1 and by sequence analysis. Limited deletions did not...

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PMID: 18974278
DOI: 10.1261/rna.1051208

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