Article
Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.
Cancer discovery - 1 Jun 2016
Spiegel Asaf, Brooks Mary W, Houshyar Samin, Reinhardt Ferenc, Ardolino Michele, Fessler Evelyn, Chen Michelle B, Krall Jordan A, DeCock Jasmine, Zervantonakis Ioannis K, Iannello Alexandre, Iwamoto Yoshiko, Cortez-Retamozo Virna, Kamm Roger D, Pittet Mikael J, Raulet David H, Weinberg Robert A
Abstract excerpt
UNLABELLED: Immune cells promote the initial metastatic dissemination of carcinoma cells from primary tumors. In contrast to their well-studied functions in the initial stages of metastasis, the specific roles of immunocytes in facilitating progression through the critical later steps of the invasion-metastasis cascade remain poorly understood. Here, we define novel functions of neutrophils in promoting...
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