Article
An optimized procedure for the design and evaluation of Ecotilling assays.
BMC genomics - 30 Oct 2008
Coassin Stefan, Brandstätter Anita, Kronenberg Florian
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) are the most common form of genetic variability in the human genome and play a prominent role in the heritability of phenotypes. Especially rare alleles with frequencies less than 5% may exhibit a particularly strong influence on the development of complex diseases. The detection of rare alleles by standard DNA sequencing is time-consuming and cost-intensive....
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