Article
TILLING: a shortcut in functional genomics.
Journal of applied genetics - 1 Nov 2011
Kurowska Marzena, Daszkowska-Golec Agata, Gruszka Damian, Marzec Marek, Szurman Miriam, Szarejko Iwona, Maluszynski Miroslaw
Abstract excerpt
Recent advances in large-scale genome sequencing projects have opened up new possibilities for the application of conventional mutation techniques in not only forward but also reverse genetics strategies. TILLING (Targeting Induced Local Lesions IN Genomes) was developed a decade ago as an alternative to insertional mutagenesis. It takes advantage of classical mutagenesis, sequence availability and...
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