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Article

A large-scale functional approach to uncover human genes and pathways in Drosophila.

Cell research - 1 Nov 2008

Xu Rong, Deng Kejing, Zhu Yi, Wu Yue, Ren Jing, Wan Min, Zhao Shouyuan, Wu Xiaohui, Han Min, Zhuang Yuan, Xu Tian

Abstract excerpt

We demonstrate the feasibility of performing a systematic screen for human gene functions in Drosophila by assaying for their ability to induce overexpression phenotypes. Over 1 500 transgenic fly lines corresponding to 236 human genes have been established. In all, 51 lines are capable of eliciting a phenotype suggesting that the human genes are functional. These heterologous genes are functionally relevant as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18957936
DOI: 10.1038/cr.2008.295

Genes

RPL8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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