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Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans

28 Oct 2008

Abstract excerpt

A well-known virulence attribute of the human-pathogenic yeast Candida albicans is the secretion of aspartic proteases (Saps), which may contribute to colonization and infection of different host niches by degrading tissue barriers, destroying host defence molecules, or digesting proteins for nutrient supply. The role of individual Sap isoenzymes, which are encoded by a large gene family, for the pathogenicity of...

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PMID: 18957582
DOI: 10.1099/mic.0.2008/022525-0

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