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Article

The Role of Secreted Aspartyl Proteinases in<i>Candida albicans</i>Keratitis

25 Jul 2007

Abstract excerpt

PURPOSE: To evaluate virulence in a murine keratitis model using Candida albicans homozygous mutants deficient in one or more secreted aspartyl proteinases encoded by SAP genes or in transcriptional factors encoded by EFG1 and CPH1 genes. METHODS: Corneas of BALB/c mice were scarified and topically inoculated with 10(6) colony-forming units of a C. albicans human isolate (SC5314), triple SAP-null mutants...

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PMID: 17652724
DOI: 10.1167/iovs.07-0114

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