Article
Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer.
Proceedings of the National Academy of Sciences of the United States of America - 4 Nov 2008
An Qian, Wright Sarah L, Konn Zoë J, Matheson Elizabeth, Minto Lynne, Moorman Anthony V, Parker Helen, Griffiths Mike, Ross Fiona M, Davies Teresa, Hall Andy G, Harrison Christine J, Irving Julie A, Strefford Jon C
Abstract excerpt
The search for target genes involved in unbalanced acquired chromosomal abnormalities has been largely unsuccessful, because the breakpoints of these rearrangements are too variable. Here, we use the example of dicentric chromosomes in B cell precursor acute lymphoblastic leukemia to show that, despite this heterogeneity, single genes are targeted through a variety of mechanisms. FISH showed that, although they...
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