Article
Angiotensin-converting enzyme genotype may predict survival following major trauma.
Emergency medicine journal : EMJ - 1 Nov 2008
Kehoe A D, Eleftheriou K I, Heron M, Coats T J, Montgomery H E
Abstract excerpt
BACKGROUND: As a key component of the endocrine renin-angiotensin system (RAS), angiotensin-converting enzyme (ACE) regulates circulatory homeostasis. Meanwhile, the local RAS influences tissue growth, inflammatory and metabolic responses. The absence (deletion, D) rather than the presence (insertion, I) of a 287 base pair fragment in the ACE gene is associated with higher circulating and tissue ACE activity,...
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