Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism.

American journal of respiratory and critical care medicine - 15 Apr 2002

Harding David, Baines Paul B, Brull David, Vassiliou Vassilis, Ellis Ian, Hart Anthony, Thomson Alistair P J, Humphries Steve E, Montgomery Hugh E

Abstract excerpt

Critical illness outcome may be causally related to inflammatory response severity. Given that tissue angiotensin-converting-enzyme (ACE) regulates such responses and that the deletion (D) [rather than insertion (I)] variant of the ACE gene is associated with higher tissue ACE levels, DD genotype might be associated with a poorer outcome in a uniform infectious disease state. Illness severity (Pediatric RIsk of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meningococcal Infections

Share to Peptidyl-Dipeptidase A

Share to Prognosis

Share to Risk Factors

Share to Sequence Deletion

Share to Survival Rate

Source

Identifiers

PMID: 11956052
DOI: 10.1164/ajrccm.165.8.2108089

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism.PMID 11956052Read ↗

Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection.Semantic proximity Read ↗

Angiotensin-converting enzyme genotype may predict survival following major trauma.Semantic proximity Read ↗

Multiple organ dysfunction syndrome in children with sepsis: role of genetic factors.Semantic proximity Read ↗

Angiotensin-converting enzyme insertion/deletion polymorphism is associated with severe hypoxemia in pediatric ARDS.Semantic proximity Read ↗

Angiotensin-Converting Enzyme 1 (ACE1) gene polymorphisms in pediatric patients with COVID-19: impact on disease severity and outcomes.Semantic proximity Read ↗

Genetic polymorphisms in host response to meningococcal infection: The role of susceptibility and severity genesSemantic proximity Read ↗

Genetic variation in pro-inflammatory cytokines and meningococcal sepsis.Semantic proximity Read ↗

Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.Semantic proximity Read ↗

Thrombin-activatable fibrinolysis inhibitor is associated with severity and outcome of severe meningococcal infection in children.Semantic proximity Read ↗

Polymorphism of angiotensin converting enzyme is associated with severe circulatory compromise in febrile neutropenic children with cancer.Semantic proximity Read ↗

Angiotensin-converting enzyme insertion/deletion polymorphism and risk and outcome of pneumonia.Semantic proximity Read ↗

Role of angiotensin-converting enzyme gene polymorphism in persistent pulmonary hypertension of the newborn.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.