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Article

Effect of mutation K85R on GSK-3beta: Molecular dynamics simulation.

Biochemical and biophysical research communications - 19 Dec 2008

Sun Hao, Jiang Yong-jun, Yu Qing-sen, Luo Cheng-cai, Zou Jian-wei

Abstract excerpt

As a serine-threonine protein kinase, glycogen synthase kinase-3 (GSK-3) regulates the synthesis of glycogen and plays important roles in several signaling pathways. It is a key therapeutic target for a number of diseases, such as diabetes, cancer, Alzheimer's disease and chronic inflammation. The conserved Lys85 is important to GSK-3beta activity and in this paper we illustrate the significant role of Lys85...

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Identifiers

PMID: 18955029
DOI: 10.1016/j.bbrc.2008.10.096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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