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Article

Modification at HuR(S242) alters HuR localization and proliferative influence.

Cell cycle (Georgetown, Tex.) - 1 Nov 2008

Kim Hyeon Ho, Yang Xiaoling, Kuwano Yuki, Gorospe Myriam

Abstract excerpt

HuR is predominantly nuclear but following exposure to stress and mitogens, it can translocate to the cytoplasm where it stabilizes target mRNAs and/or modulates their translation. Several phosphorylation sites in a central 'hinge" region of HuR have been reported to affect its nucleocytoplasmic shuttle: phosphorylation by PKC at serine (S)221 and by Cdk1 at S202. Here, we investigated if there are additional...

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Identifiers

PMID: 18948743
DOI: 10.4161/cc.7.21.6895
PMCID: PMC2704553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modification at HuR(S242) alters HuR localization and proliferative influence.PMID 18948743Read ↗

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