Article
Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans.
Pharmacogenetics and genomics - 1 Jun 2008
Huang Rong Stephanie, Duan Shiwei, Kistner Emily O, Zhang Wei, Bleibel Wasim K, Cox Nancy J, Dolan M Eileen
Abstract excerpt
OBJECTIVES: The very important pharmacogenes (VIPs) were selected by Pharmacogenetic Research Network (National Institutes of Health-PGRN) owing to their significant effects on drug treatment both at the pharmacokinetic and pharmacodynamic levels. Our objective was to identify single nucleotide polymorphisms (SNPs) that potentially affected the expression of these genes or potential SNP-gene interactions involved...
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